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Anaplastic oligodendroglioma

MedGen UID:
90812
•Concept ID:
C0334590
•
Neoplastic Process
Synonyms: Anaplastic Oligodendroglioma; Anaplastic Oligodendrogliomas; Oligodendroglioma, Anaplastic; Oligodendrogliomas, Anaplastic
SNOMED CT: Anaplastic oligodendroglioma (3102004); Oligodendroglioma, anaplastic (3102004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0016696
Orphanet: ORPHA251630

Definition

A rare glial tumor characterized by a grade III oligodendroglial tumour with focal or diffuse anaplastic features. It typically occurs in the supratentorial white matter. Histologically, the cells are enlarged and epithelioid with pleomorphic and increased size nuclei, a vesicular chromatin pattern and prominent nucleoli. Most patients present with seizures. [from ORDO]

Professional guidelines

PubMed

Clinical importance of eflornithine (α-difluoromethylornithine) for the treatment of malignant gliomas.
Levin VA, Ictech SE, Hess KR
CNS Oncol 2018 Apr;7(2):CNS16. Epub 2018 Jan 30 doi: 10.2217/cns-2017-0031. PMID: 29378419Free PMC Article
Clinical utility and treatment outcome of comprehensive genomic profiling in high grade glioma patients.
Blumenthal DT, Dvir A, Lossos A, Tzuk-Shina T, Lior T, Limon D, Yust-Katz S, Lokiec A, Ram Z, Ross JS, Ali SM, Yair R, Soussan-Gutman L, Bokstein F
J Neurooncol 2016 Oct;130(1):211-219. Epub 2016 Aug 16 doi: 10.1007/s11060-016-2237-3. PMID: 27531351
Anaplastic glioma: current treatment and management.
Le Rhun E, Taillibert S, Chamberlain MC
Expert Rev Neurother 2015 Jun;15(6):601-20. Epub 2015 May 2 doi: 10.1586/14737175.2015.1042455. PMID: 25936680

Recent clinical studies

Etiology

Anaplastic glioma: current treatment and management.
Le Rhun E, Taillibert S, Chamberlain MC
Expert Rev Neurother 2015 Jun;15(6):601-20. Epub 2015 May 2 doi: 10.1586/14737175.2015.1042455. PMID: 25936680
Glioblastoma and other malignant gliomas: a clinical review.
Omuro A, DeAngelis LM
JAMA 2013 Nov 6;310(17):1842-50. doi: 10.1001/jama.2013.280319. PMID: 24193082
Adjuvant procarbazine, lomustine, and vincristine chemotherapy in newly diagnosed anaplastic oligodendroglioma: long-term follow-up of EORTC brain tumor group study 26951.
van den Bent MJ, Brandes AA, Taphoorn MJ, Kros JM, Kouwenhoven MC, Delattre JY, Bernsen HJ, Frenay M, Tijssen CC, Grisold W, Sipos L, Enting RH, French PJ, Dinjens WN, Vecht CJ, Allgeier A, Lacombe D, Gorlia T, Hoang-Xuan K
J Clin Oncol 2013 Jan 20;31(3):344-50. Epub 2012 Oct 15 doi: 10.1200/JCO.2012.43.2229. PMID: 23071237
Malignant glioma: neuropathology and neurobiology.
Preusser M, Haberler C, Hainfellner JA
Wien Med Wochenschr 2006 Jun;156(11-12):332-7. doi: 10.1007/s10354-006-0304-7. PMID: 16944363
Malignant gliomas.
Burton EC, Prados MD
Curr Treat Options Oncol 2000 Dec;1(5):459-68. doi: 10.1007/s11864-000-0073-2. PMID: 12057153

Diagnosis

Recombinant polio-rhinovirus immunotherapy for recurrent paediatric high-grade glioma: a phase 1b trial.
Thompson EM, Landi D, Brown MC, Friedman HS, McLendon R, Herndon JE 2nd, Buckley E, Bolognesi DP, Lipp E, Schroeder K, Becher OJ, Friedman AH, McKay Z, Walter A, Threatt S, Jaggers D, Desjardins A, Gromeier M, Bigner DD, Ashley DM
Lancet Child Adolesc Health 2023 Jul;7(7):471-478. Epub 2023 Mar 30 doi: 10.1016/S2352-4642(23)00031-7. PMID: 37004712Free PMC Article
Anaplastic glioma: current treatment and management.
Le Rhun E, Taillibert S, Chamberlain MC
Expert Rev Neurother 2015 Jun;15(6):601-20. Epub 2015 May 2 doi: 10.1586/14737175.2015.1042455. PMID: 25936680
Malignant glioma: neuropathology and neurobiology.
Preusser M, Haberler C, Hainfellner JA
Wien Med Wochenschr 2006 Jun;156(11-12):332-7. doi: 10.1007/s10354-006-0304-7. PMID: 16944363
Oligodendroglioma and anaplastic oligodendroglioma: clinical features, treatment, and prognosis.
Engelhard HH, Stelea A, Mundt A
Surg Neurol 2003 Nov;60(5):443-56. doi: 10.1016/s0090-3019(03)00167-8. PMID: 14572971
Malignant gliomas.
Burton EC, Prados MD
Curr Treat Options Oncol 2000 Dec;1(5):459-68. doi: 10.1007/s11864-000-0073-2. PMID: 12057153

Therapy

Recombinant polio-rhinovirus immunotherapy for recurrent paediatric high-grade glioma: a phase 1b trial.
Thompson EM, Landi D, Brown MC, Friedman HS, McLendon R, Herndon JE 2nd, Buckley E, Bolognesi DP, Lipp E, Schroeder K, Becher OJ, Friedman AH, McKay Z, Walter A, Threatt S, Jaggers D, Desjardins A, Gromeier M, Bigner DD, Ashley DM
Lancet Child Adolesc Health 2023 Jul;7(7):471-478. Epub 2023 Mar 30 doi: 10.1016/S2352-4642(23)00031-7. PMID: 37004712Free PMC Article
Clinical importance of eflornithine (α-difluoromethylornithine) for the treatment of malignant gliomas.
Levin VA, Ictech SE, Hess KR
CNS Oncol 2018 Apr;7(2):CNS16. Epub 2018 Jan 30 doi: 10.2217/cns-2017-0031. PMID: 29378419Free PMC Article
Bevacizumab and other novel therapies for recurrent oligodendroglial tumors.
Grimm SA, Chamberlain MC
CNS Oncol 2015;4(5):333-9. Epub 2015 Oct 28 doi: 10.2217/cns.15.27. PMID: 26509217Free PMC Article
Oligodendroglioma and anaplastic oligodendroglioma: clinical features, treatment, and prognosis.
Engelhard HH, Stelea A, Mundt A
Surg Neurol 2003 Nov;60(5):443-56. doi: 10.1016/s0090-3019(03)00167-8. PMID: 14572971
Malignant gliomas.
Burton EC, Prados MD
Curr Treat Options Oncol 2000 Dec;1(5):459-68. doi: 10.1007/s11864-000-0073-2. PMID: 12057153

Prognosis

Treatment Outcomes in 1p19q Co-deleted/Partially Deleted Gliomas.
McNamara MG, Jiang H, Lim-Fat MJ, Sahebjam S, Kiehl TR, Karamchandani J, Coire C, Chung C, Millar BA, Laperriere N, Mason WP
Can J Neurol Sci 2017 May;44(3):288-294. doi: 10.1017/cjn.2016.420. PMID: 28488951
Oligodendrogliomas in Children: Clinical Experiences With 20 Patients.
Wu CT, Tsay PK, Jaing TH, Chen SH, Tseng CK, Jung SM
J Pediatr Hematol Oncol 2016 Oct;38(7):555-8. doi: 10.1097/MPH.0000000000000610. PMID: 27299589
Malignant glioma: neuropathology and neurobiology.
Preusser M, Haberler C, Hainfellner JA
Wien Med Wochenschr 2006 Jun;156(11-12):332-7. doi: 10.1007/s10354-006-0304-7. PMID: 16944363
Oligodendroglioma and anaplastic oligodendroglioma: clinical features, treatment, and prognosis.
Engelhard HH, Stelea A, Mundt A
Surg Neurol 2003 Nov;60(5):443-56. doi: 10.1016/s0090-3019(03)00167-8. PMID: 14572971
Malignant gliomas.
Burton EC, Prados MD
Curr Treat Options Oncol 2000 Dec;1(5):459-68. doi: 10.1007/s11864-000-0073-2. PMID: 12057153

Clinical prediction guides

Acid and Alkaline Phosphatases Specific activities and Expression as Biomarkers in Brain Tumor Grading and Correlation of Anaplastic Oligodendroglioma G-III to Meningiomas G-I among Brain Tumors and their primary culture.
Muddobalaiah P, Ravi V, Thammanna CC, Sagar BKC, Swamy NSR
J Chem Neuroanat 2022 Nov;125:102140. Epub 2022 Jul 30 doi: 10.1016/j.jchemneu.2022.102140. PMID: 35914649
Clinical discussion of the management of anaplastic oligodendroglioma/oligoastrocytoma (both codeleted and nondeleted).
Anderson MD, Gilbert MR
J Natl Compr Canc Netw 2014 May;12(5):665-72. doi: 10.6004/jnccn.2014.0070. PMID: 24812135
Anaplastic oligodendroglioma: a new treatment paradigm and current controversies.
Roth P, Wick W, Weller M
Curr Treat Options Oncol 2013 Dec;14(4):505-13. doi: 10.1007/s11864-013-0251-7. PMID: 23907441
Chemotherapeutic options for primary brain tumors.
Kim L, Glantz M
Curr Treat Options Oncol 2006 Nov;7(6):467-78. doi: 10.1007/s11864-006-0022-9. PMID: 17032559
Oligodendroglioma and anaplastic oligodendroglioma: clinical features, treatment, and prognosis.
Engelhard HH, Stelea A, Mundt A
Surg Neurol 2003 Nov;60(5):443-56. doi: 10.1016/s0090-3019(03)00167-8. PMID: 14572971

Recent systematic reviews

Diagnostic test accuracy and cost-effectiveness of tests for codeletion of chromosomal arms 1p and 19q in people with glioma.
McAleenan A, Jones HE, Kernohan A, Robinson T, Schmidt L, Dawson S, Kelly C, Spencer Leal E, Faulkner CL, Palmer A, Wragg C, Jefferies S, Brandner S, Vale L, Higgins JP, Kurian KM
Cochrane Database Syst Rev 2022 Mar 2;3(3):CD013387. doi: 10.1002/14651858.CD013387.pub2. PMID: 35233774Free PMC Article
Chemotherapy plus radiotherapy versus radiotherapy alone in patients with anaplastic glioma: a systematic review and meta-analysis.
Zhang L, Wu X, Xu T, Luo C, Qian J, Lu Y
J Cancer Res Clin Oncol 2013 May;139(5):719-26. Epub 2013 Feb 10 doi: 10.1007/s00432-013-1387-3. PMID: 23397358
Adjuvant chemotherapy for adults with malignant glioma: a systematic review.
Perry J, Laperriere N, Zuraw L, Chambers A, Spithoff K, Cairncross JG; Neuro-oncology Disease Site Group; Cancer Care Ontario Program in Evidence-Based Care
Can J Neurol Sci 2007 Nov;34(4):402-10. doi: 10.1017/s0317167100007265. PMID: 18062446

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